前沿速览027期| CAR-T治B淋 前沿览新知

01

组蛋白标记识别新型转录因子,解析CAR-T细胞的起源亚群、临床潜力和扩增能力
Histone marks identify novel transcription factors that parse CAR-T subset-of-origin, clinical potential and expansion
第一作者:Fiorenza S
Nat Commun (IF=14.7). 2024 Sep 27;15(1):8309.
全文网址:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436946/
02

神经丝轻链蛋白水平可作为CAR-T细胞疗法相关神经毒性的早期预测生物标志物
Neurofilament light chain levels as an early predictive biomarker of neurotoxicity after CAR T-cell therapy
第一作者:Larue M
J Immunother Cancer (IF=10.3). 2024 Sep 24;12(9):e009525.
全文网址:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423758/
03

Lisocabtagene maraleucel作为R/R LBCL的社区门诊或住院治疗的II期研究
OUTREACH: Phase 2 study of lisocabtagene maraleucel as outpatient or inpatient treatment at community sites for R/R LBCL
第一作者:Linhares Y
Blood Adv (IF=7.4). 2024 Sep 30:bloodadvances.2024013254.
全文网址:https://ashpublications.org/bloodadvances/article/doi/10.1182/bloodadvances.2024013254/518001/OUTREACH-Phase-2-study-of-lisocabtagene-maraleucel
04

CAR-T细胞治疗期间,回输间充质干细胞可恢复造血功能并解决血细胞减少症
Mesenchymal stem cell infusion for enhancing hematopoietic recovery and addressing cytopenias in CAR-T cell therapy
第一作者:Xia Y
Stem Cell Res Ther (IF=7.1). 2024 Sep 27;15(1):333.
全文网址:https://stemcellres.biomedcentral.com/articles/10.1186/s13287-024-03941-8
05

桥接放疗后接受CAR-T细胞疗法的侵袭性B细胞淋巴瘤患者,其淋巴细胞减少症特征以及与放射剂量和受照射骨髓体积相关的血细胞减少症风险
Characterization of lymphopenia and correlating the risk of cytopenias with dose and BM volume irradiated in aggressive B-cell lymphoma patients bridged with radiation therapy for CAR-T cell therapy
第一作者:Manzar GS
Int J Radiat Oncol Biol Phys (IF=6.4). 2024 Sep 18:S0360-3016(24)03394-7.
全文网址:https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(24)03394-7
06

CAR-T细胞治疗复发/难治性套细胞淋巴瘤:系统综述和荟萃分析
Chimeric antigen receptor T-cell therapy in relapsed or refractory mantle cell lymphoma: a systematic review and meta-analysis
第一作者:Wan H
Front Immunol (IF=5.7). 2024 Sep 6;15:1435127.
全文网址:https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1435127/full
07

(18)F-FDG PET参数在接受CAR-T细胞治疗的淋巴瘤患者中的预后价值:系统综述和荟萃分析
The prognostic utility of (18)F-FDG PET parameters in lymphoma patients under CAR-T-cell therapy: a systematic review and meta-analysis
第一作者:Al-Ibraheem A
Front Immunol (IF=5.7). 2024 Sep 2;15:1424269.
全文网址:https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1424269/full
08

弥漫大B细胞淋巴瘤免疫治疗的未来展望
The future of immunotherapy for diffuse large B-cell lymphoma
第一作者:Duell J
Int J Cancer (IF=5.7). 2024 Sep 25.
全文网址:https://onlinelibrary.wiley.com/doi/10.1002/ijc.35156
09

CARs的未来展望:CAR-T细胞疗法在血液恶性肿瘤早期治疗中的进展
CARs Moving Forward: The Development of CAR T-Cell Therapy in the Earlier Treatment Course of Hematologic Malignancies
第一作者:Castaneda Puglianini O
Semin Hematol (IF=5.0). 2024 Aug 24:S0037-1963(24)00089-1.
全文网址:https://www.sciencedirect.com/science/article/abs/pii/S0037196324000891
10

CAR-T细胞治疗后第一年内的生活质量和患者报告的毒性反应:一项前瞻性评估
Prospective Assessment of Quality of Life and Patient-Reported Toxicities Over the First Year After Chimeric Antigen Receptor T-Cell Therapy
第一作者:Hoogland AI
Transplant Cell Ther (IF=3.6). 2024 Sep 19:S2666-6367(24)00666-3.
全文网址:https://linkinghub.elsevier.com/retrieve/pii/S2666-6367(24)00666-3
免责声明:本资料为专业医学资料,旨在促进医药信息的沟通和交流,仅供医疗卫生专业人士参考;任何处方请参考产品最新详细处方资料。本文件可能包含涉及医学情况、健康及治疗方法的信息。相关信息不得用作诊断或治疗,不能替代专业医学意见。
审批编号:NP-NHL-2024.10-8 valid until 2026.10
供稿与审核:临床开发与医学部