中文

2024-10-16

前沿速览028期| CAR-T治B淋 前沿览新知


01

我如何治疗复发/难治性弥漫大B细胞淋巴瘤老年患者

How I Treat Older Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma


第一作者:Wallace DS


Blood (IF=21.0). 2024 Oct 2:blood.2024024788.   


全文网址:https://ashpublications.org/blood/article/doi/10.1182/blood.2024024788/518020/How-I-Treat-Older-Patients-with-Relapsed

02

(68)Ga-grazytracer PET用于无创评估实体瘤和淋巴瘤患者对免疫疗法的应答:一项I/II期临床试验 

(68)Ga-grazytracer PET for noninvasive assessment of response to immunotherapy in solid tumors and lymphomas: a phase 1/2 clinical trial


第一作者:Shen X


Nat Commun (IF=14.7). 2024 Oct 10;15(1):8791. 

 

全文网址:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467221/


03

CAR-T细胞治疗晚期血液系统恶性肿瘤后的心血管事件:一项荟萃分析

Cardiovascular Events After Chimeric Antigen Receptor T-Cell Therapy for Advanced Hematologic Malignant Neoplasms: A Meta-Analysis


第一作者:Koeckerling D


JAMA Netw Open (IF=10.5). 2024 Oct 1;7(10):e2437222. 


全文网址:https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2824532


04

C-CAR066(一种新型全人源抗CD20 CAR-T细胞疗法),用于抗CD19 CAR-T细胞治疗失败后的复发/难治性大B细胞淋巴瘤患者:一项I期临床研究

C-CAR066, a novel fully human anti-CD20 CAR-T therapy for relapsed or refractory large B-cell lymphoma after failure of anti-CD19 CAR-T therapy: A phase I clinical study


第一作者:Li P


Am J Hematol (IF=10.1). 2024 Oct 1. 


全文网址:https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajh.27488


05

自体移植后应用CD19/CD22 CAR-T细胞鸡尾酒疗法可作为治疗复发/难治性中枢神经系统淋巴瘤的优化策略

CD19/CD22 CAR-T-cell cocktail therapy following autologous transplantation is an optimizing strategy for treating relapsed/refractory central nervous system lymphoma


第一作者:Zhou X


Exp Hematol Oncol (IF=9.4). 2024 Oct 13;13(1):100. 


全文网址:https://ehoonline.biomedcentral.com/articles/10.1186/s40164-024-00538-y


06

在中枢神经系统淋巴瘤中,CAR-T细胞疗法前的桥接放疗

Bridging radiotherapy before CAR-T therapy in CNS lymphoma


第一作者:Bacher U


Blood Adv (IF=7.4). 2024 Oct 8;8(19):5190-5191. 


全文网址:https://ashpublications.org/bloodadvances/article/8/19/5190/518072/Bridging-radiotherapy-before-CAR-T-therapy-in-CNS

07

病例报告:一例伴有系统性红斑狼疮和抗磷脂综合征的B细胞淋巴瘤患者在接受抗CD19 CAR-T细胞治疗后,抗磷脂抗体消失

Disappearance of Antiphospholipid Antibodies after anti-CD19 CAR T-Cell Therapy of B-Cell Lymphoma in a Patient with Systemic Lupus Erythematosus and Antiphospholipid Syndrome


第一作者:Friedberg E


J Thromb Haemost (IF=5.5). 2024 Oct 9:S1538-7836(24)00572-5. 


全文网址:https://linkinghub.elsevier.com/retrieve/pii/S1538-7836(24)00572-5

08

桥接放疗在CAR-T细胞治疗复发/难治性弥漫大B细胞淋巴瘤患者中的作用:一项多中心研究

Role of bridging RT in relapsed/refractory diffuse large B-cell lymphoma undergoing CAR-T therapy: a multicenter study


第一作者:Bramanti S


Bone Marrow Transplant (IF=4.5). 2024 Oct 9. 


全文网址:https://www.nature.com/articles/s41409-024-02427-8

09

疾病稳定/进展的大B细胞淋巴瘤患者清淋期间,根据CAR-T细胞扩增情况附加纳武利尤单抗治疗:一项II期前瞻性干预研究

Addition of nivolumab tailored by expansion of CAR-T cells in patients with stable/progressive large B cell lymphoma at lymphodepletion - a phase 2, prospective interventional study


第一作者:Ram R


Transplant Cell Ther (IF=3.6). 2024 Oct 11:S2666-6367(24)00692-4. 


全文网址:https://linkinghub.elsevier.com/retrieve/pii/S2666-6367(24)00692-4

10

表达CXCR5蛋白的CD19 CAR-T细胞治疗复发/难治性B细胞淋巴瘤:一项I期临床试验

Phase I Clinical Trial of CD19 CAR-T Cells Expressing CXCR5 Protein for the Treatment of Relapsed or Refractory B-cell Lymphoma


第一作者:Wang J


Curr Cancer Drug Targets (IF=2.3). 2024 Sep 27. 


全文网址:https://www.eurekaselect.com/article/143412


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审批编号:NP-NHL-2024.10-16 valid until 2026.10


供稿与审核:临床开发与医学部