前沿速览020期| CAR-T治B淋 前沿览新知

01

Lisocabtagene maraleucel治疗滤泡性淋巴瘤:II期TRANSCEND FL研究
Lisocabtagene maraleucel in follicular lymphoma: the phase 2 TRANSCEND FL study
第一作者:Morschhauser F
Nat Med (IF=82.9). 2024 Jun 3.
全文网址:https://www.nature.com/articles/s41591-024-02986-9
02

BTLA-HVEM轴限制了CAR-T治疗癌症的疗效
The BTLA-HVEM axis restricts CAR T cell efficacy in cancer
第一作者:Guruprasad P
Nat Immunol (IF=30.5). 2024 Jun;25(6):1020-1032.
全文网址:https://www.nature.com/articles/s41590-024-01847-4
03

皮下可降解生物支架可用于重新激发预先输注的CAR-T细胞的抗肿瘤活性
Subcutaneous biodegradable scaffolds for restimulating the antitumour activity of pre-administered CAR-T cells
第一作者:Zhang DKY
Nat Biomed Eng (IF=28.1). 2024 Jun 3.
全文网址:https://www.nature.com/articles/s41551-024-01216-4
04
一种用于自动制备CAR-T细胞的高密度微流控生物反应器
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells
第一作者:Sin WX
Nat Biomed Eng (IF=28.1). 2024 Jun 4.
全文网址:https://www.nature.com/articles/s41551-024-01219-1
05

CAR+细胞外囊泡可预测接受CD19 CAR-T细胞治疗的B细胞淋巴瘤患者的ICANS
CAR+ extracellular vesicles predict ICANS in patients with B cell lymphomas treated with CD19-directed CAR T cells
第一作者:Storci G
J Clin Invest (IF=15.9). 2024 Jun 4:e173096.
全文网址:http://www.jci.org/articles/view/173096
06

放疗可作为接受CAR-T细胞治疗的复发或难治性大B细胞淋巴瘤患者的桥接策略
Radiotherapy as a bridging strategy for patients with relapsed or refractory large B-cell lymphoma undergoing CAR T-cell therapy
第一作者:Ababneh HS
Am J Hematol (IF=12.8). 2024 Jun 11.
全文网址:https://onlinelibrary.wiley.com/doi/10.1002/ajh.27409
07

CD19 CAR-T治疗复发或难治性大B细胞淋巴瘤老年患者:一项多中心研究
Anti-CD19 chimeric antigen receptor T-cell therapy in older patients with relapsed or refractory large B-cell lymphoma: A multicenter study
第一作者:Tun AM
Am J Hematol (IF=12.8). 2024 Jun 4.
全文网址:https://onlinelibrary.wiley.com/doi/10.1002/ajh.27381
08

双特异性抗体和自体CAR-T治疗血液恶性肿瘤
Bispecific antibodies and autologous chimeric antigen receptor T cell therapies for treatment of hematological malignancies
第一作者:Al Hadidi S
Mol Ther (IF=12.4). 2024 May 31:S1525-0016(24)00341-1.
全文网址:https://linkinghub.elsevier.com/retrieve/pii/S1525-0016(24)00341-1
09

Brexucabtagene autoleucel治疗英国复发或难治性套细胞淋巴瘤患者:一项真实世界意向治疗分析
Brexucabtagene autoleucel for relapsed or refractory mantle cell lymphoma in the United Kingdom: A real-world intention-to-treat analysis
第一作者:O'Reilly MA
Hemasphere (IF=9.1). 2024 Jun 13;8(6):e87.
全文网址:https://onlinelibrary.wiley.com/doi/10.1002/hem3.87
10

CAR-T治疗侵袭性B细胞淋巴瘤之前,对中枢神经系统进行桥接放疗可实现快速的细胞减灭
CNS Bridging Radiotherapy Achieves Rapid Cytoreduction Prior to CAR T Cell Therapy for Aggressive B-Cell Lymphoma
第一作者:Cederquist G
Blood Adv (IF=7.6). 2024 Jun 11:bloodadvances.2024013393.
全文网址:https://ashpublications.org/bloodadvances/article/doi/10.1182/bloodadvances.2024013393/516464/CNS-Bridging-Radiotherapy-Achieves-Rapid
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审批编号:NP-NHL-2024.6-16 valid until 2026.6
供稿与审核:临床开发与医学部