前沿速览040期| CAR-T治B淋 前沿览新知

01

非霍奇金淋巴瘤对CAR-T细胞治疗反应的炎症生物标志物特征
An inflammatory biomarker signature of response to CAR-T cell therapy in non-Hodgkin lymphoma
第一作者:Raj SS
Nat Med (IF=58.7). 2025 Apr 1.
全文网址:https://www.nature.com/articles/s41591-025-03532-x
02

Glofitamab用于CAR-T细胞治疗失败后的复发/难治性弥漫大B细胞淋巴瘤:一项II期的LYSA研究
Glofitamab in refractory or relapsed diffuse large B cell lymphoma after failing CAR-T cell therapy: a phase 2 LYSA study
第一作者:Cartron G
Nat Cancer (IF=23.5). 2025 Apr 3.
全文网址:https://www.nature.com/articles/s43018-025-00941-2
03

弥漫大B细胞淋巴瘤中CAR-T细胞治疗反应因结外病变部位而异
CAR T-cell therapy response varies by extranodal disease site in large B-cell lymphoma
第一作者:Luna A
Blood Cancer J (IF=12.9). 2025 Apr 14;15(1):64.
全文网址:https://www.nature.com/articles/s41408-025-01273-1
04

大B细胞淋巴瘤结外受累部位的特异性分析揭示了CAR-T细胞治疗的疗效差异
Site-specific analysis of extranodal involvement in large B-cell lymphoma reveals distinct efficacy with chimeric antigen receptor T-cell therapy
第一作者:Iacoboni G
Leukemia (IF=12.8). 2025 Apr 1.
全文网址:https://www.nature.com/articles/s41375-025-02582-x
05

在B细胞非霍奇金淋巴瘤中,既往化疗会降低用于制备CAR-T细胞产品的T细胞质量
Prior chemotherapy deteriorates T-cell quality for CAR T-cell therapy in B-cell non-Hodgkin's lymphoma
第一作者:Junkuhn C
J Immunother Cancer (IF=10.3). 2025 Apr 9;13(4):e010709.
全文网址:https://pmc.ncbi.nlm.nih.gov/articles/PMC11987159/
06

自体移植或CAR-T细胞疗法作为伴MYC基因重排大B细胞淋巴瘤患者挽救性治疗缓解后的巩固治疗选择
Autologous Transplant or CAR-T as Consolidation Options in MYC Rearranged Large B-Cell Lymphoma Patients in Remission After Salvage Treatments
第一作者:Furqan F
Am J Hematol (IF=10.1). 2025 Apr 15.
全文网址:https://onlinelibrary.wiley.com/doi/10.1002/ajh.27687
07

回输前18F-FDG PET/CT用于接受CAR-T细胞治疗的B细胞非霍奇金淋巴瘤患者的预后和毒性预测
Pre-infusion 18F-FDG PET/CT for Prognostic and Toxicity Prediction in B-cell Non-Hodgkin Lymphoma Patients Undergoing Chimeric Antigen Receptor T-cell Therapy
第一作者:Yao X
Clin Nucl Med (IF=10.0). 2025 Apr 7.
全文网址:https://journals.lww.com/nuclearmed/abstract/9900/pre_infusion_18f_fdg_pet_ct_for_prognostic_and.1639.aspx
08

整合基因特征用于接受CAR-T细胞治疗的中国B细胞淋巴瘤患者的预后评估
Integrating genomic features for prognosis in Chinese patients with B-cell lymphoma following chimeric antigen receptor T-cell therapya
第一作者:Zhou L
Sci China Life Sci (IF=8.0). 2025 Apr 3.
全文网址:https://link.springer.com/article/10.1007/s11427-024-2783-2
09

CAR-T细胞治疗B细胞淋巴瘤前的放疗桥接:一项多中心的ILROG研究
Bridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cells for B-Cell Lymphomas: An ILROG Multicenter Study
第一作者:Yegya-Raman N
Blood Adv (IF=7.4). 2025 Apr 9:bloodadvances.2025015855.
全文网址:https://ashpublications.org/bloodadvances/article/doi/10.1182/bloodadvances.2025015855/536662/Bridging-Radiotherapy-Prior-to-Chimeric-Antigen
10

5-5-5 ABRT(适应性桥接放疗: 5周内最多5次,每次5Gy)——人工智能助力CAR-T细胞疗法在复发/难治性大B细胞淋巴瘤中的应用
5-5-5 ABRT (Dose of 5 Gy per Fraction for up to 5 Fractions Over 5 Weeks Adaptive Bridging Radiation Therapy)-Artificial Intelligence Enters the CAR (-T) (Chimeric Antigen Receptor-T) in Relapsed/Refractory Large B Cell Lymphoma
第一作者:Ababneh HS
Int J Radiat Oncol Biol Phys (IF=6.4). 2025 Apr 3:S0360-3016(25)00251-2.
全文网址:https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(25)00251-2
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审批编号:NP-NHL-2025.4-17 valid until 2027.4
供稿与审核:临床开发与医学部